ANTI-ARRHYTHMIC DRUGS

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Anti-arrhythmic drug therapy for atrial fibrillation: current anti-arrhythmic drugs, investigational agents, and innovative approaches.

By 2050, atrial fibrillation (AF) will be present in 2% of the general population and in a far higher proportion of elderly patients. Currently, we are content with rate control and anticoagulation in elderly asymptomatic patients, whereas in younger patients with symptomatic recurrent AF, pulmonary vein isolation is the treatment of choice. However, in a large number of patients, there remains...

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Fish oil--an appetising alternative to anti-arrhythmic drugs?

See page 1441 Observational and trial data have accumulated to support the hypothesis that increased consumption of the longchain n-3 polyunsaturated fatty acids found in fish, especially eicosapentaenoic and docosahexaenoic acids, lower the risk of dying from coronary heart disease, and interest has focused on the anti-arrhythmic properties of these fatty acids. In the late 1980s, McClennan et...

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Interactions of Rosiglitazone and Anti-Arrhythmic Drugs in Animal Model

BACKGROUND Diabetes increases the risk of vascular problems by two times compared with a healthy individual, with deposition of fats in blood vessel and this includes cardiovascular disease. The treatment regimens for patients suffering from both diseases generally include prolonged use of anti-diabetic drugs for diabetes and anti-arrhythmic drugs for cardiac arrhythmias. AIM The aim of the s...

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Omega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both?

PURPOSE OF REVIEW Recent publications seem to indicate no or an untoward effect of the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on cardiac rhythm. This review puts these developments into perspective. RECENT FINDINGS In-vitro or in animal models, little pro-arrhythmic effect, but many antiarrhythmic mechanisms of omega-3 fatty acids have been documented. In in...

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Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

INTRODUCTION Hypertrophic cardiomyopathy (HCM) is a cause of sudden arrhythmic death, but the understanding of its pro-arrhythmic mechanisms and an effective pharmacological treatment are lacking. HCM electrophysiological remodelling includes both increased inward and reduced outward currents, but their role in promoting repolarisation abnormalities remains unknown. The goal of this study is to...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1979

ISSN: 0007-0912

DOI: 10.1093/bja/51.7.659